E2 enzymes
E2 enzymes (Ubiquitin-conjugating enzymes) perform the second step in the ubiquitination reaction that targets a protein for degradation via the proteasome.The ubiquitination process covalently attaches ubiquitin, a short protein of 76 amino acids, to a lysine residue on the target protein. Once a protein has been tagged with one ubiquitin molecule, additional rounds of ubiquitination form a polyubiquitin chain that is recognized by the proteasome's 19S regulatory particle, triggering the ATP-dependent unfolding of the target protein that allows passage into the proteasome's 20S core particle, where proteases degrade the target into short peptide fragments for recycling by the cell.
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LP 12 hydrochloride是5-HT7激动剂。
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LP 20 hydrochloride是选择性5-HT7配体。
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LP 44是高亲和性5-HT7激动剂。
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Lofepramine是5-HT，noradrenalin re-uptake inhibitor（SNRI，摄取抑制剂）。
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L-703，664 succinate是选择性 5-HT1D 受体激动剂。
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