E2 enzymes
E2 enzymes (Ubiquitin-conjugating enzymes) perform the second step in the ubiquitination reaction that targets a protein for degradation via the proteasome.The ubiquitination process covalently attaches ubiquitin, a short protein of 76 amino acids, to a lysine residue on the target protein. Once a protein has been tagged with one ubiquitin molecule, additional rounds of ubiquitination form a polyubiquitin chain that is recognized by the proteasome's 19S regulatory particle, triggering the ATP-dependent unfolding of the target protein that allows passage into the proteasome's 20S core particle, where proteases degrade the target into short peptide fragments for recycling by the cell.
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MK 212 hydrochloride是5-HT2C 激动剂。
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Milnacipran hydrochloride是5-HT，noradrenalin re-uptake inhibitor (SNRI)去甲肾上腺素重吸收抑制剂。
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Methysergide maleate是5-HT1/5-HT2 拮抗剂。
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Methiothepin maleate是对5-HT5有适度的亲核性，对5-ht6和5-HT7 有高亲和性。 也是 5-HT1 和 5-HT2的拮抗剂。
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Methoxyresorufin是荧光CYP450底物（fluorometric CYP450 substrate）。
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