E2 enzymes
E2 enzymes (Ubiquitin-conjugating enzymes) perform the second step in the ubiquitination reaction that targets a protein for degradation via the proteasome.The ubiquitination process covalently attaches ubiquitin, a short protein of 76 amino acids, to a lysine residue on the target protein. Once a protein has been tagged with one ubiquitin molecule, additional rounds of ubiquitination form a polyubiquitin chain that is recognized by the proteasome's 19S regulatory particle, triggering the ATP-dependent unfolding of the target protein that allows passage into the proteasome's 20S core particle, where proteases degrade the target into short peptide fragments for recycling by the cell.
-
N-Acetyltryptamine是5 羟色胺N-乙酰转移酶的底物。
More
-
NAD 299 hydrochloride是选择性， 高亲和性 5-HT1A 拮抗剂。
More
-
MS 245 oxalate是高亲和性 5-HT6 拮抗剂。
More
-
MM 77 dihydrochloride是5-HT1A (postsynaptic) 的拮抗剂。
More
-
ML 10302 hydrochloride是活性的，选择性 5-HT4 部分激动剂。
More
