E2 enzymes
E2 enzymes (Ubiquitin-conjugating enzymes) perform the second step in the ubiquitination reaction that targets a protein for degradation via the proteasome.The ubiquitination process covalently attaches ubiquitin, a short protein of 76 amino acids, to a lysine residue on the target protein. Once a protein has been tagged with one ubiquitin molecule, additional rounds of ubiquitination form a polyubiquitin chain that is recognized by the proteasome's 19S regulatory particle, triggering the ATP-dependent unfolding of the target protein that allows passage into the proteasome's 20S core particle, where proteases degrade the target into short peptide fragments for recycling by the cell.
-
RS 39604 hydrochloride是5-HT4 拮抗剂。
More
-
Roxindole hydrochloride是Roxindole hydrochloride is a dopamine D2 autoreceptor agonist and has affinity for D3, D4, 5-HT1A receptors and the 5-HT transporter.。
More
-
Ro 60-0175 fumarate是活性选择性 5-HT2C 激动剂。
More
-
Ro 04-6790是活性选择性 5-HT6 拮抗剂。
More
-
Ritanserin是活性的 5-HT2 拮抗剂。
More
