E2 enzymes
E2 enzymes (Ubiquitin-conjugating enzymes) perform the second step in the ubiquitination reaction that targets a protein for degradation via the proteasome.The ubiquitination process covalently attaches ubiquitin, a short protein of 76 amino acids, to a lysine residue on the target protein. Once a protein has been tagged with one ubiquitin molecule, additional rounds of ubiquitination form a polyubiquitin chain that is recognized by the proteasome's 19S regulatory particle, triggering the ATP-dependent unfolding of the target protein that allows passage into the proteasome's 20S core particle, where proteases degrade the target into short peptide fragments for recycling by the cell.
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RU 24969 hemisuccinate是5-HT1B/1A 激动剂。
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RS 102221 hydrochloride是选择性 5-HT2C 拮抗剂。
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RS 127445 hydrochloride是选择性， 高亲和性 5-HT2B 拮抗剂。
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RS 16566 dihydrochloride是5-HT3 配体。 也对扎考必利的结合位点有强的亲和力（zacopride binding site）。
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RS 23597-190 hydrochloride是5-HT4 拮抗剂。
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