E2 enzymes
E2 enzymes (Ubiquitin-conjugating enzymes) perform the second step in the ubiquitination reaction that targets a protein for degradation via the proteasome.The ubiquitination process covalently attaches ubiquitin, a short protein of 76 amino acids, to a lysine residue on the target protein. Once a protein has been tagged with one ubiquitin molecule, additional rounds of ubiquitination form a polyubiquitin chain that is recognized by the proteasome's 19S regulatory particle, triggering the ATP-dependent unfolding of the target protein that allows passage into the proteasome's 20S core particle, where proteases degrade the target into short peptide fragments for recycling by the cell.
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Spiperone hydrochloride是5-HT2A 拮抗剂。 也是D2样受体拮抗剂。
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SQ 22536是Adenylyl cyclase 抑制剂。
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SGS 518 oxalate是选择性 5-HT6 拮抗剂。
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SDZ SER 082 fumarate是选择性 5-HT2B/2C 拮抗剂。
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SDZ 205-557 hydrochloride是5-HT4/5-HT3 受体拮抗剂。
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