E2 enzymes
E2 enzymes (Ubiquitin-conjugating enzymes) perform the second step in the ubiquitination reaction that targets a protein for degradation via the proteasome.The ubiquitination process covalently attaches ubiquitin, a short protein of 76 amino acids, to a lysine residue on the target protein. Once a protein has been tagged with one ubiquitin molecule, additional rounds of ubiquitination form a polyubiquitin chain that is recognized by the proteasome's 19S regulatory particle, triggering the ATP-dependent unfolding of the target protein that allows passage into the proteasome's 20S core particle, where proteases degrade the target into short peptide fragments for recycling by the cell.
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(S)-WAY 100135 dihydrochloride是活性的， 选择性 5-HT1A 拮抗剂。
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(R)-(+)-8-Hydroxy-DPAT hydrobromide是选择性 5-HT1A 激动剂。8-Hydroxy-DPAT hydrobromide的对映体之一 。
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(±)-MDMA hydrochloride是5-HT，dopamine uptake inhibitor， hallucinogenic activity。
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(±)-McN 5652是活性的， 口服活性的5-HT 吸收抑制剂。体外也能抑制 noradrenalin，dopamine的吸收。
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Zotepine是5-HT2A/D2 拮抗剂， 非典型的抗精神病药物（antipsychotic）。
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