E2 enzymes
E2 enzymes (Ubiquitin-conjugating enzymes) perform the second step in the ubiquitination reaction that targets a protein for degradation via the proteasome.The ubiquitination process covalently attaches ubiquitin, a short protein of 76 amino acids, to a lysine residue on the target protein. Once a protein has been tagged with one ubiquitin molecule, additional rounds of ubiquitination form a polyubiquitin chain that is recognized by the proteasome's 19S regulatory particle, triggering the ATP-dependent unfolding of the target protein that allows passage into the proteasome's 20S core particle, where proteases degrade the target into short peptide fragments for recycling by the cell.
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3-Cyano-7-ethoxycoumarin是Fluorescent cytochrome P450 substrate。
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3-AQC是5-HT3 拮抗剂。
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2-Methyl-5-hydroxytryptamine hydrochloride是5-HT3 激动剂/活性的 5-HT6 配体。
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2-[1-(4-Piperonyl)piperazinyl]benzothiazole是5-HT4 激动剂。 也是5-HT3 拮抗剂。
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1-Methylpsilocin是活性的，选择性 5-HT2C 激动剂。
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