E2 enzymes
E2 enzymes (Ubiquitin-conjugating enzymes) perform the second step in the ubiquitination reaction that targets a protein for degradation via the proteasome.The ubiquitination process covalently attaches ubiquitin, a short protein of 76 amino acids, to a lysine residue on the target protein. Once a protein has been tagged with one ubiquitin molecule, additional rounds of ubiquitination form a polyubiquitin chain that is recognized by the proteasome's 19S regulatory particle, triggering the ATP-dependent unfolding of the target protein that allows passage into the proteasome's 20S core particle, where proteases degrade the target into short peptide fragments for recycling by the cell.
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ATC 0175 hydrochloride是MCH1 拮抗剂， 也是5-HT2B 拮抗剂，5-HT1A 部分 激动剂。
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AT 1015是Long-acting 5-HT2A 拮抗剂。
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Anpirtoline hydrochloride是高 活性的 5-HT1B 激动剂。 也是5-HT3 拮抗剂。
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Altanserin hydrochloride是5-HT2A 受体拮抗剂。
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A 80426 mesylate是高亲和性 α2 拮抗剂。 也是 5-HT uptake inhibitor（摄取抑制剂）。
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