p53
Tumor protein p53, also known as p53, cellular tumor antigen p53 (UniProt name), phosphoprotein p53, tumor suppressor p53, antigen NY-CO-13, or transformation-related protein 53 (TRP53), is any isoform of a protein encoded by homologous genes in various organisms, such as TP53 (humans) and Trp53 (mice). This homolog is crucial in multicellular organisms, where it prevents cancer formation, thus, functions as a tumor suppressor. p53 has many mechanisms of anticancer function and plays a role in apoptosis, genomic stability, and inhibition of angiogenesis.
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PRIMA-1MET是Restores mutant p53 activity。
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PRIMA-1是Restores mutant p53 activity， induces apoptosis。
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PhiKan 083 is a p53 stabilizing agent。
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NSC 146109 hydrochloride是细胞膜通透性的基因型选择性抗肿瘤试剂， 激活p53依赖型转录。
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MIRA-1是Restores mutant p53 activity， proapoptotic。
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