Bcl-2
Bcl-2 (B-cell lymphoma 2), encoded in humans by the BCL2 gene, is the founding member of the Bcl-2 family of regulator proteins that regulate cell death (apoptosis), by either inducing (pro-apoptotic) or inhibiting (anti-apoptotic) apoptosis. Bcl-2 is specifically considered an important anti-apoptotic protein but it is NOT considered a proto-oncogene because it is not a growth signal transducer.BCL-2 is localized to the outer membrane of mitochondria, where it plays an important role in promoting cellular survival and inhibiting the actions of pro-apoptotic proteins.
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BAM 7是一种直接的，选择性的是凋亡相关Bax的激动剂,EC50为3.3 μM。
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Sabutoclax是一种pan-Bcl-2抑制剂，作用于Bcl-xL， Bcl-2， Mcl-1和Bfl-1，IC50分别为0.31 μM， 0.32 μM， 0.20 μM和0.62 μM。
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TW-37是新型非肽类Bcl-2，Bcl-xL和Mcl-1抑制剂，Ki分别为290 nM，1.11 μM和260 nM。
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HA14-1是非肽类Bcl-2表面口袋配体，IC50为9 μM。
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