JAK
Janus kinase (JAK) is a family of intracellular, nonreceptor tyrosine kinases that transduce cytokine-mediated signals via the JAK-STAT pathway. The four JAK family members are:Janus kinase 1 (JAK1),Janus kinase 2 (JAK2),Janus kinase 3 (JAK3) and Tyrosine kinase 2 (TYK2).JAK inhibitors are under development for the treatment of psoriasis, rheumatoid arthritis, polycythemia vera, alopecia, essential thrombocythemia, ulcerative colitis, myeloid metaplasia with myelofibrosis and vitiligo.
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NVP-BSK805是ATP竞争性JAK2抑制剂，IC50为0.5 nM，比对JAK1，JAK3和TYK2的抑制性高超出20倍。
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NVP-BSK805是ATP竞争性JAK2抑制剂，IC50为0.5 nM，比对JAK1，JAK3和TYK2的抑制性高超出20倍。
More
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NVP-BSK805是ATP竞争性JAK2抑制剂，IC50为0.5 nM，比对JAK1，JAK3和TYK2的抑制性高超出20倍。
More
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NVP-BSK805是ATP竞争性JAK2抑制剂，IC50为0.5 nM，比对JAK1，JAK3和TYK2的抑制性高超出20倍。
More
