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Bromodomain(BRD)


A bromodomain is an approximately 110 amino acid protein domain that recognizes acetylated lysine residues, such as those on the N-terminal tails of histones. Bromodomains are responsible in transducing the signal carried by acetylated lysine residues and translating it into various normal or abnormal phenotypes. Bromodomain-containing proteins can have a wide variety of functions, ranging from histone acetyltransferase activity and chromatin remodeling to transcriptional mediation and co-activation.
  • CPI-203 EY0503

    CPI 203是可渗透入细胞的高活性BET家族蛋白BRD4抑制剂,IC50为37 nM。

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