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PARs


Protease-activated receptors are a subfamily of related G protein-coupled receptors that are activated by cleavage of part of their extracellular domain. They are highly expressed in platelets, but also on endothelial cells, myocytes and neurons.Most of the PAR family act through the actions of G-proteins i (cAMP inhibitory), 12/13 (Rho and Ras activation) and q (calcium signalling) to cause cellular actions.

  • Q94 hydrochloride EI2281

    Q94 hydrochloride是PAR1 受体的阴性变构的调节剂（negative allosteric modulator）。

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  • ML 354 EI1726

    ML 354是选择性 PAR4 拮抗剂。

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  • ML 161 EI1705

    ML 161是PAR1-mediated platelet activation inhibition。

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  • Q94 hydrochloride EI2281

    Q94 hydrochloride是PAR1 受体的阴性变构的调节剂（negative allosteric modulator）。

    More

  • ML 354 EI1726

    ML 354是选择性 PAR4 拮抗剂。

    More

  • ML 161 EI1705

    ML 161是PAR1-mediated platelet activation inhibition。

    More
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