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RARs/RXR


RAR (The retinoic acid receptor) is a type of nuclear receptor which can also act as a transcription factor that is activated by both all-trans retinoic acid and 9-cis retinoic acid. There are three retinoic acid receptors (RAR), RAR-alpha, RAR-beta, and RAR-gamma. Each receptor isoform has several splice variants: four- for alpha, four- for beta, and two- for gamma. RXR (The retinoid X receptor) is a type of nuclear receptor that is activated by 9-cis retinoic acid. There are three retinoic X receptors (RXR): RXR-alpha, RXR-beta, and RXR-gamma. RXR heterodimerizes with subfamily 1 nuclear receptors including CAR, FXR, LXR, PPAR, PXR, RAR, TR, and VDR.

  • BMS 961 EI0600

    BMS 961是选择性 RARγ 激动剂。

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  • BMS 753 EI0599

    BMS 753是RARα-选择性激动剂。

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  • BMS 493 EI0595

    BMS 493是Pan-RAR 反向激动剂。

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  • BMS 195614 EI0591

    BMS 195614是选择性 RARα 拮抗剂。

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  • Bexarotene EI0559

    Bexarotene是活性的，选择性 RXR 激动剂。

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