HSP
HSPs are a family of proteins that are produced by cells in response to exposure to stressful conditions. Many members of this group perform chaperone function by stabilizing new proteins to ensure correct folding or by helping to refold proteins that were damaged by the cell stress. This increase in expression is transcriptionally regulated. The dramatic upregulation of the heat shock proteins is a key part of the heat shock response and is induced primarily by heat shock factor (HSF). Heat-shock proteins are named according to their molecular weight. For example, Hsp60, Hsp70 and Hsp90 (the most widely studied HSPs) refer to families of heat shock proteins on the order of 60, 70, and 90 kilodaltons in size, respectively. The small 8-kilodalton protein ubiquitin, which marks proteins for degradation, also has features of a heat shock protein. Heat Shock Factor 1 (HSF1) is a transcription factor that is involved in the general maintenance and upregulation of Hsp70 protein expression. HSF1 inhibition by a potent RNA aptamer attenuates mitogenic (MAPK) signaling and induces cancer cell apoptosis.
-
Radicicol是Hsp90 抑制剂。有抗真菌和抗细菌的活性。。
More
-
Macbecin I是Hsp90 抑制剂。
More
-
17-DMAG (Alvespimycin) HCl是一种水溶性HSP90抑制剂，IC50为62 nM。
More
-
Ganetespib (STA-9090)是一种HSP90抑制剂，作用于OSA 8种细胞，IC50为4 nM，诱导OSA细胞凋亡，而对正常的成骨细胞无作用；是STA-1474的活性代谢物。
More
-
17-AAG (Tanespimycin)是一种有效的HSP90抑制剂，IC50为5 nM，作用于从肿瘤细胞提取的HSP90比作用于从正常细胞提取的HSP90结合亲和力高100倍。
More
-
Radicicol是Hsp90 抑制剂。有抗真菌和抗细菌的活性。。
More
-
Macbecin I是Hsp90 抑制剂。
More
-
17-DMAG (Alvespimycin) HCl是一种水溶性HSP90抑制剂，IC50为62 nM。
More
-
Ganetespib (STA-9090)是一种HSP90抑制剂，作用于OSA 8种细胞，IC50为4 nM，诱导OSA细胞凋亡，而对正常的成骨细胞无作用；是STA-1474的活性代谢物。
More
-
17-AAG (Tanespimycin)是一种有效的HSP90抑制剂，IC50为5 nM，作用于从肿瘤细胞提取的HSP90比作用于从正常细胞提取的HSP90结合亲和力高100倍。
More
