mGluR
MGluRs are a type of glutamate receptor that are active through an indirect metabotropic process. They are members of the group C family of G-protein-coupled receptors, or GPCRs. Like all glutamate receptors, mGluRs bind with glutamate, an amino acid that functions as an excitatory neurotransmitter. Like other metabotropic receptors, mGluRs have seven transmembrane domains that span the cell membrane. Unlike ionotropic receptors, metabotropic glutamate receptors are not ion channels. Instead, they activate biochemical cascades, leading to the modification of other proteins, as for example ion channels. This can lead to changes in the synapse's excitability, for example by presynaptic inhibition of neurotransmission, or modulation and even induction of postsynaptic responses. Eight different types of mGluRs, labeled mGluR1 to mGluR8 (GRM1 to GRM8), are divided into groups I, II, and III. Receptor types are grouped based on receptor structure and physiological activity. The mGluRs are further divided into subtypes, such as mGluR7a and mGluR7b.
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LY 456236 hydrochloride是选择性 mGlu1 拮抗剂。
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LY 487379 hydrochloride是选择性mGlu2的阳性变构的调节剂（positive allosteric modulator）。
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LY 341495是高活性的选择性 group II 拮抗剂。
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LY 354740是活性高选择性 group II mGlu 激动剂。
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LY 367385是选择性 mGlu1a 拮抗剂。
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LY 456236 hydrochloride是选择性 mGlu1 拮抗剂。
More
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LY 487379 hydrochloride是选择性mGlu2的阳性变构的调节剂（positive allosteric modulator）。
More
-
LY 341495是高活性的选择性 group II 拮抗剂。
More
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LY 354740是活性高选择性 group II mGlu 激动剂。
More
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LY 367385是选择性 mGlu1a 拮抗剂。
More
