COX
Cyclooxygenase (COX) is an enzyme (specifically, a family of isozymes) that is responsible for formation of prostanoids, including thromboxane and prostaglandins such as prostacyclin. Pharmaceutical inhibition of COX can provide relief from the symptoms of inflammation and pain. Nonsteroidal anti-inflammatory drugs (NSAIDs), such as aspirin and ibuprofen, exert their effects through inhibition of COX. The two isozymes found in human are called COX-1 and COX-2 in the medical literature.
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Trometamol is a proton acceptor used to treat academia.
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Mefenamic acid is a competitive inhibitor of COX-1 and COX-2.
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Nabumetone is a non-steroidal anti-inflammatory drug and its active metabolite inhibits the COX.
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Antipyrine is an analgesic and antipyretic agent.
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Zaltoprofen is an inhibitor of Cox-1 and Cox-2 for treatment of arthritis.
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