Cannabinoid Receptor
Cannabinoid receptors, located throughout the body, are part of the Endocannabinoid system which is involved in a variety of physiological processes including appetite, pain-sensation, mood, and memory.
Cannabinoid receptors are of a class of cell membrane receptors under the G protein-coupled receptor superfamily. As is typical of G protein-coupled receptors, the cannabinoid receptors contain seven transmembrane spanning domains. Cannabinoid receptors are activated by three major groups of ligands: endocannabinoids, produced by the mammillary body; plant cannabinoids; and synthetic cannabinoids. There are currently two known subtypes of cannabinoid receptors, termed CB1 and CB2.
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2-Arachidonylglycerol是内源性 cannabinoid 激动剂， 活性的 GPR55 激动剂。
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(R)-(+)-Methanandamide是活性的，选择性 CB1 激动剂。
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(±)-SLV 319是活性的，选择性 CB1 受体 拮抗剂。
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(±)-CP 47497是活性的 CB1 激动剂。
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(-)-Cannabidiol是Natural cannabinoid， GPR55 拮抗剂， 弱效 CB1 拮抗剂， CB2反相激动剂，AMT的抑制剂。
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