Adenosine Receptor
The adenosine receptors (P1 receptors) are a class of purinergic G protein-coupled receptors with adenosine as endogenous ligand. In humans, there are four types of adenosine receptors(A1,A2A ,A2B,A3). Each is encoded by a separate gene and has different functions, although with some overlap. For instance, both A1 receptors and A2A play roles in the heart, regulating myocardial oxygen consumption and coronary blood flow, while the A2A receptor also has broader anti-inflammatory effects throughout the body. These two receptors also have important roles in the brain, regulating the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors are located mainly peripherally and are involved in processes such as inflammation and immune responses.
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SCH 442416是高选择性和高亲和性的A2A拮抗剂。
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PSB 0788是选择性 A2B 拮抗剂。
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PSB 10 hydrochloride是活性高选择性 hA3 受体拮抗剂/反向激动剂。
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PSB 11 hydrochloride是活性选择性 hA3 受体拮抗剂/反向激动剂。
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PSB 1115是选择性人 A2B 受体拮抗剂，具有水溶性。
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