MMPs
MMPs (Matrix metalloproteinases) are calcium-dependent zinc-containing endopeptidases; other family members are adamalysins, serralysins, and astacins. The MMPs belong to a larger family of proteases known as the These enzymes are capable of degrading all kinds of extracellular matrix proteins, but also can process a number of bioactive molecules. They are known to be involved in the cleavage of cell surface receptors, the release of apoptotic ligands (such as the FAS ligand), and chemokine/cytokine inactivation.[3] MMPs are also thought to play a major role in cell behaviors such as cell proliferation, migration (adhesion/dispersion), differentiation, angiogenesis, apoptosis, and host defense.
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PD 166793是广谱的 MMP 抑制剂。
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ONO 4817是Broad spectrum MMP 抑制剂。
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GM6001 (galardin, ilomastat)是泛MMP抑制剂，对MMP-1，MMP-2，MMP-3，MMP-7，MMP-8，MMP-9，MMP-12，MMP-14和MMP-26的Ki为0.4-27 nM。
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SB-3CT是Gelatinase高效选择性抑制剂，对MMP2和MMP9的Ki值分别为13.9nM和600nM。
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Batimastat (BB-94)是一种广谱MMP（基质金属蛋白酶）抑制剂，作用于MMP-1， MMP-2， MMP-9， MMP-7和MMP-3，IC50分别为3 nM， 4 nM， 4 nM， 6 nM和20 nM。
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