Topoisomerase
Topoisomerases are enzymes that participate in the overwinding or underwinding of DNA. During DNA replication and transcription, DNA becomes overwound ahead of a replication fork. If left unabated, this torsion would eventually stop the ability of DNA or RNA polymerases involved in these processes to continue down the DNA strand.Topoisomerases are isomerase enzymes that act on the topology of DNA.Bacterial topoisomerase and human topoisomerase proceed via the same mechanism for replication and transcription.
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Enoxacin(Penetrex)is an oral broad-spectrum fluoroquinolone antibacterial agent used in the treatment of urinary tract infections and gonorrhea. Insomnia is a common adverse effect.
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Norfloxacin is a broad-spectrum antibiotic which is a fluorinated quinolone Pefloxacin derivative.Norfloxacin blocks DNA replication by interfering with an ATP-induced structural transition of DNA complexed with DNA gyrase (topoisomerase).
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Ellipticine是抗肿瘤活性，可抑制 DNA topoisomerase II ，可作为插入试剂（intercalating agent） 。
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CPT 11是DNA topoisomerase I 抑制剂有抗肿瘤活性。
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Banoxantrone dihydrochloride是Prodrug topoisomerase II 抑制剂。
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