Clofarabine is a potent HIV-1 inhibitor in both activated CD4+ T cells and macrophages. Clofarabine inhibits the enzymatic activities of ribonucleotide reductase (IC50 = 65 nM) and DNA polymerase
MoreCisplatin是一种无机的水溶性的铂配合物,通过形成DNA交联剂而抑制DNA合成。
MoreSCR7 is a specific DNA Ligase IV inhibitor (IC50 = 40 nM in Hela and A549 cell).
MoreGemcitabine HCl是一种DNA合成抑制剂,作用于PANC1, MIAPaCa2, BxPC3和Capan2细胞时,IC50分别为50 nM, 40 nM, 18 nM和12 nM。
MoreOxaliplatin通过与DNA交联而抑制DNA合成。
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