Wnt/beta-catenin
β-catenin (Catenin beta-1) is a dual function protein, involved in regulation and coordination of cell–cell adhesion and gene transcription. In cardiac muscle, beta-catenin localizes to adherens junctions in intercalated disc structures, which are critical for electrical and mechanical coupling between adjacent cardiomyocyte.
-
IWP-2抑制Wnt信号和分泌，IC50为27 nM，选择性抑制Porcn介导的Wnt棕榈酰化，一般不影响Wnt/β-catenin，且对Wnt刺激的细胞反应没有影响。
More
-
IWP L6是高活性Porcn抑制剂，EC50为0.5 nM。
More
-
WIKI4 is a potent inhibitor of Wnt/β-catenin signaling (EC50 ~ 75 nM) that inhibits auto-ADP-ribosylation of tankyrase 2 (TNKS2) (IC50 ~15 nM).
More
-
IWP-2抑制Wnt信号和分泌，IC50为27 nM，选择性抑制Porcn介导的Wnt棕榈酰化，一般不影响Wnt/β-catenin，且对Wnt刺激的细胞反应没有影响。
More
-
IWP L6是高活性Porcn抑制剂，EC50为0.5 nM。
More
-
WIKI4 is a potent inhibitor of Wnt/β-catenin signaling (EC50 ~ 75 nM) that inhibits auto-ADP-ribosylation of tankyrase 2 (TNKS2) (IC50 ~15 nM).
More
