Wnt/beta-catenin
The Wnt signaling pathways are a group of signal transduction pathways made of proteins that pass signals into a cell through cell surface receptors. Three Wnt signaling pathways have been characterized: the canonical Wnt pathway, the noncanonical planar cell polarity pathway, and the noncanonical Wnt/calcium pathway. All three pathways are activated by binding a Wnt-protein ligand to a Frizzled family receptor, which passes the biological signal to the Dishevelled protein inside the cell. Wnt signaling pathways use either nearby cell-cell communication (paracrine) or same-cell communication (autocrine).
Catenin beta-1 also known as β-catenin is a protein that in humans is encoded by the CTNNB1 gene.
β-catenin is a dual function protein, regulating the coordination of cell–cell adhesion and gene transcription. β-catenin is a subunit of the cadherin protein complex and acts as an intracellular signal transducer in the Wnt signaling pathway. It is a member of the catenin protein family and homologous to γ-catenin, also known as plakoglobin. Beta-catenin is widely expressed in many tissues.Mutations and overexpression of β-catenin are associated with many cancers, including hepatocellular carcinoma, colorectal carcinoma, lung cancer, malignant breast tumors, ovarian and endometrial cancer.
Wnt signaling and the elevated level of beta-catenin in certain cell types is the maintenance of pluripotency.
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IWP-2抑制Wnt信号和分泌，IC50为27 nM，选择性抑制Porcn介导的Wnt棕榈酰化，一般不影响Wnt/β-catenin，且对Wnt刺激的细胞反应没有影响。
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IWP L6是高活性Porcn抑制剂，EC50为0.5 nM。
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WIKI4 is a potent inhibitor of Wnt/β-catenin signaling (EC50 ~ 75 nM) that inhibits auto-ADP-ribosylation of tankyrase 2 (TNKS2) (IC50 ~15 nM).
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IWP-2抑制Wnt信号和分泌，IC50为27 nM，选择性抑制Porcn介导的Wnt棕榈酰化，一般不影响Wnt/β-catenin，且对Wnt刺激的细胞反应没有影响。
More
-
IWP L6是高活性Porcn抑制剂，EC50为0.5 nM。
More
-
WIKI4 is a potent inhibitor of Wnt/β-catenin signaling (EC50 ~ 75 nM) that inhibits auto-ADP-ribosylation of tankyrase 2 (TNKS2) (IC50 ~15 nM).
More
