PKC
PKC (Protein kinase C) is a family of protein kinase enzymes that are involved in controlling the function of other proteins through the phosphorylation of hydroxyl groups of serine and threonine amino acid residues on these proteins, or a member of this family. PKC enzymes in turn are activated by signals such as increases in the concentration of diacylglycerol (DAG) or calcium ions (Ca2+). Hence PKC enzymes play important roles in several signal transduction cascades.
The PKC family consists of fifteen isozymes in humans. They are divided into three subfamilies, based on their second messenger requirements: conventional (or classical), novel, and atypical.
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Masitinib, a novel phenylaminothiazole-type derivative, is an inhibitor of the class III receptor tyrosine kinase stem-cell growth factor receptor (c-Kit) with IC50 of 200 nM, platelet-derived growth factor receptor α and β and the non-receptor tyrosine kinase Lyn(PDGFRα/β with IC50 of 540 nM/800 nM).
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FR 236924是选择性 PKCε 激动剂。
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D-erythro-Sphingosine (synthetic)是Protein kinase C（PKC） 抑制剂。
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CID 2858522是选择性抑制 PKC诱导的 NF-κB 激活。
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CGP 53353是PKCβII选择性抑制剂。
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Masitinib, a novel phenylaminothiazole-type derivative, is an inhibitor of the class III receptor tyrosine kinase stem-cell growth factor receptor (c-Kit) with IC50 of 200 nM, platelet-derived growth factor receptor α and β and the non-receptor tyrosine kinase Lyn(PDGFRα/β with IC50 of 540 nM/800 nM).
More
-
FR 236924是选择性 PKCε 激动剂。
More
-
D-erythro-Sphingosine (synthetic)是Protein kinase C（PKC） 抑制剂。
More
-
CID 2858522是选择性抑制 PKC诱导的 NF-κB 激活。
More
-
CGP 53353是PKCβII选择性抑制剂。
More
