Potassium Channel


potassium channels are the most widely distributed type of ion channel and are found in virtually all living organisms. They form potassium-selective pores that span cell membranes. Furthermore potassium channels are found in most cell types and control a wide variety of cell functions. These channels act to set or reset the resting potential in many cells. In excitable cells, such as neurons, the delayed counterflow of potassium ions shapes the action potential.
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    Milrinone是一种有效的,选择性的磷酸二酯酶-3抑制剂,抑制FIII PDE,IC50为0.42 μM。

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    Gliquidone是一种磺酰脲类的抗糖尿病药物, 用于治疗2型糖尿病。

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    Cilomilast是一种有效的PDE4抑制剂,IC50为110 nM,具有抗炎活性和弱的中枢神经系统活性。

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