Potassium Channel
potassium channels are the most widely distributed type of ion channel and are found in virtually all living organisms. They form potassium-selective pores that span cell membranes. Furthermore potassium channels are found in most cell types and control a wide variety of cell functions. These channels act to set or reset the resting potential in many cells. In excitable cells, such as neurons, the delayed counterflow of potassium ions shapes the action potential.
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Roflumilast 是一种选择性的PDE-4抑制剂，IC50为0.2-4.3 nM。
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Dipyridamole是磷酸二酯酶抑制剂，能阻断红细胞和血管内皮细胞对腺苷的吸收和代谢。
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Apremilast是一种口服生物有效的PDE4和TNF-α抑制剂，IC50分别为74 nM和77 nM。
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Sildenafil citrate是磷酸二酯酶5（PDE-5）抑制剂，IC50为5.22 nM，可能是最好的可作用于勃起功能紊乱的化合物。
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Vardenafil是PDE5抑制剂，可作用于勃起功能障碍。
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