Potassium Channel
potassium channels are the most widely distributed type of ion channel and are found in virtually all living organisms. They form potassium-selective pores that span cell membranes. Furthermore potassium channels are found in most cell types and control a wide variety of cell functions. These channels act to set or reset the resting potential in many cells. In excitable cells, such as neurons, the delayed counterflow of potassium ions shapes the action potential.
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Amiodarone hydrochloride is a lipophilic antiarrhythmic/antianginal drug which is able to influence the physicochemical status of biological lipid components.
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Repaglinide是氨基甲酰甲基苯甲酸(CMBA)衍生物,可作用于II型糖尿病。
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Dofetilide是III型抗心律失常药,能阻断钾离子通道。
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Cilostazol 是存在于心血管系统中的PDE3A抑制剂,IC50为200 nM。
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Aminophylline是一种竞争性的,非选择性的磷酸二酯酶抑制剂,IC50为0.12 mM,也是非选择性的腺苷受体拮抗剂。
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