VDAC
VDAC (Voltage-dependent anion channels) are a class of porin ion channel located on the outer mitochondrial membrane. VDAC facilitates the exchange of ions and molecules between mitochondria and cytosol and is regulated by the interactions with other proteins and small molecules. The voltage-dependent ion channel plays a key role in regulating metabolic and energetic flux across the outer mitochondrial membrane.
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Metolazone(Zaroxolyn) is an inhibitor of thiazide-sensitive Na+-Cl- cotransporter; antihypertensive; moderate "loop" diuretic.It is primarily used to treat congestive heart failure and high blood pressure.
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Pralatrexate(Folotyn) is an inhibitor of DHFR (dihydrofolate reductase). Its IC50 is < 300 nM in some cell lines.
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IDE 2是IDE 2 induces definitive endoderm formation in mouse and human ESCs.。
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ICA 110381是KV7.2/7.3 激动剂具有抗惊厥活性。
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ICI 185，282是活性的 thromboxane 受体拮抗剂。
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