VDAC


VDAC (Voltage-dependent anion channels) are a class of porin ion channel located on the outer mitochondrial membrane. VDAC facilitates the exchange of ions and molecules between mitochondria and cytosol and is regulated by the interactions with other proteins and small molecules. The voltage-dependent ion channel plays a key role in regulating metabolic and energetic flux across the outer mitochondrial membrane. 
  • Nitrofurazone EY2266

    Nitrofurazone is antimicrobial.Nitrofural is a topical anti-infective agent with an IC50 of 22.83 ± 1.2 μM. (Rat LD50 = 590 mg/kg).

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  • Lactulose EY2251

    Lactulose is a keto analogue of lactose, a disaccharide composed of galactose and fructose. It is a stimulator of health-promoting bacterium growth in the gastrointestinal tract, used to treat chronic constipation and hepatic encephalopathy.

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  • Methimazole EY2256

    Methimazole(Tapazole, Northyx) is an antithyroid medicine. It is an antithyroid compound found to have antioxidant properties. Methimazole inhibits activation of the IFN-g-induced Janus kinase (JAK)/STAT signaling pathway in FRTL-5 thyroid cells, which may account for its immunodolulatory effects. Additionally, methimazole is an inhibitor of thyroperoxidase.

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  • Metolazone EY2257

    Metolazone(Zaroxolyn) is an inhibitor of thiazide-sensitive Na+-Cl- cotransporter; antihypertensive; moderate "loop" diuretic.It is primarily used to treat congestive heart failure and high blood pressure.

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  • Pralatrexate EY2248

    Pralatrexate(Folotyn) is an inhibitor of DHFR (dihydrofolate reductase). Its IC50 is < 300 nM in some cell lines.

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