VDAC
VDAC (Voltage-dependent anion channels) are a class of porin ion channel located on the outer mitochondrial membrane. VDAC facilitates the exchange of ions and molecules between mitochondria and cytosol and is regulated by the interactions with other proteins and small molecules. The voltage-dependent ion channel plays a key role in regulating metabolic and energetic flux across the outer mitochondrial membrane.
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Silibinin为抗癌和化疗预防化合物，能抑制细胞增殖和迁移。
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URMC-099是MLK3口服活性，脑渗透性抑制剂，IC50值14nM，抑制脂多糖诱导的小胶质细胞TNF的释放。
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Laquinimod是一种中枢神经系统（CNS）免疫调节剂。0.1-1 μM Laquinimod 处理不影响外周血单核细胞(PBMC)活性。通过在健康对象和复发缓解型多发性硬化症(RRMS)患者的PBMC中进行大规模基因表达芯片分析 ,显示 Laquinimod 抑制与抗原呈递及相应炎症通路相关的基因表达。Laquinimod作用于CD14+ 和 CD4+细胞，诱导Th2反应激活，作用于CD8+细胞，抑制增殖。
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Ascorbic acid是天然有机物，有抗氧化活性。
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Cholesterol是哺乳动物中主要的甾体类化合物，在基本的细胞生命活动中起到重要作用。
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