VDAC
VDAC (Voltage-dependent anion channels) are a class of porin ion channel located on the outer mitochondrial membrane. VDAC facilitates the exchange of ions and molecules between mitochondria and cytosol and is regulated by the interactions with other proteins and small molecules. The voltage-dependent ion channel plays a key role in regulating metabolic and energetic flux across the outer mitochondrial membrane.
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Ezetimibe是胆固醇吸收抑制剂,能降低LDL胆固醇的水平。
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STF-118804是烟酰胺磷酸核糖基转移酶Nampt高选择性抑制剂,细胞viability IC50小于10nM。
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(-)-p-Bromotetramisole Oxalate 是强效的非特异性的碱性磷酸酶抑制剂。
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Idebenone (艾地苯醌) 是合成的辅酶Q10的变体,最初用于阿尔茨海默症和其它的认知缺陷。
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SBE13盐酸盐是PLK1激酶高效选择性抑制剂,IC50值为0.2nM,对Aurora A、PLK2和PLK3基本无抑制。
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