VDAC
VDAC (Voltage-dependent anion channels) are a class of porin ion channel located on the outer mitochondrial membrane. VDAC facilitates the exchange of ions and molecules between mitochondria and cytosol and is regulated by the interactions with other proteins and small molecules. The voltage-dependent ion channel plays a key role in regulating metabolic and energetic flux across the outer mitochondrial membrane.
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Idebenone (艾地苯醌) 是合成的辅酶Q10的变体,最初用于阿尔茨海默症和其它的认知缺陷。
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SBE13盐酸盐是PLK1激酶高效选择性抑制剂,IC50值为0.2nM,对Aurora A、PLK2和PLK3基本无抑制。
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Rifabutin是半合成的安莎霉素抗生素,具有抗分枝杆菌特性。
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Pexidartinib是受体酪氨酸激酶Fms,Kit和Flt3小分子抑制剂,临床2期。
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Vancomycin hydrochloride是窄谱的糖肽抗菌剂。
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