VDAC
VDAC (Voltage-dependent anion channels) are a class of porin ion channel located on the outer mitochondrial membrane. VDAC facilitates the exchange of ions and molecules between mitochondria and cytosol and is regulated by the interactions with other proteins and small molecules. The voltage-dependent ion channel plays a key role in regulating metabolic and energetic flux across the outer mitochondrial membrane.
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Azaguanine-8是一种嘌呤类似物,具有抗肿瘤活性,在代谢中与鸟嘌呤竞争。
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RBC8是Ral GTPas抑制剂,在H2122和H358细胞中的IC50值分别为3.5和3.4uM。
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Pentamidine双盐酸盐是抗菌剂,是一种 PRL Phosphatases 抑制剂,也可以抑制DNA, RNA和蛋白质的合成。
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Ezetimibe是胆固醇吸收抑制剂,能降低LDL胆固醇的水平。
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STF-118804是烟酰胺磷酸核糖基转移酶Nampt高选择性抑制剂,细胞viability IC50小于10nM。
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