VDAC
VDAC (Voltage-dependent anion channels) are a class of porin ion channel located on the outer mitochondrial membrane. VDAC facilitates the exchange of ions and molecules between mitochondria and cytosol and is regulated by the interactions with other proteins and small molecules. The voltage-dependent ion channel plays a key role in regulating metabolic and energetic flux across the outer mitochondrial membrane.
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Atglistatin 是一种高度选择性adipose triglyceride lipase (ATGL) 抑制剂,其IC50为0.7 μM.
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Orlistat是脂肪酶抑制剂,IC50为122 ng/ml。
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Chloroxine是合成的抗生素,对头皮屑和脂溢性皮炎有效。
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Bimatoprost是前列腺素类似物,可作用于眼内高压和青光眼。
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Dimesna与癌症化疗药物联合使用以降低尿毒性。
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