VDAC
VDAC (Voltage-dependent anion channels) are a class of porin ion channel located on the outer mitochondrial membrane. VDAC facilitates the exchange of ions and molecules between mitochondria and cytosol and is regulated by the interactions with other proteins and small molecules. The voltage-dependent ion channel plays a key role in regulating metabolic and energetic flux across the outer mitochondrial membrane.
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Zileuton是一种口服有效的5-脂氧合酶抑制剂,因而可抑制白三烯(LTB 4,LTC 4,LTD 4和LTE 4)的形成。
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(S)-crizotinib是一种强效的MTH1 (NUDT1)抑制剂,其IC50为72 nM。
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GSK650394是SGK抑制剂,对SGK1和SGK2的IC50分别为62 nM和103 nM。
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Azomycin是Nocardia mesenterica产生的抗生素。
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Ro3280是一种有效的,高选择性Polo-like kinase 1(PLK1)抑制剂,IC50为3 nM。
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