VDAC
VDAC (Voltage-dependent anion channels) are a class of porin ion channel located on the outer mitochondrial membrane. VDAC facilitates the exchange of ions and molecules between mitochondria and cytosol and is regulated by the interactions with other proteins and small molecules. The voltage-dependent ion channel plays a key role in regulating metabolic and energetic flux across the outer mitochondrial membrane.
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Sal003是eIF2α phosphatase高效细胞渗透性抑制剂,Salubrinal的水溶性类似物。
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Doxapram hydrochloride hydrate (盐酸多沙普仑水合物) 能抑制TASK-1,TASK-3和TASK-1/TASK-3异二聚体通道,EC50分别为410 nM,37 μM和9 μM。
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Rheochrysidin 是大承气汤的主要成分之一,用于治疗炎症。
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Zileuton是一种口服有效的5-脂氧合酶抑制剂,因而可抑制白三烯(LTB 4,LTC 4,LTD 4和LTE 4)的形成。
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(S)-crizotinib是一种强效的MTH1 (NUDT1)抑制剂,其IC50为72 nM。
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