VDAC
VDAC (Voltage-dependent anion channels) are a class of porin ion channel located on the outer mitochondrial membrane. VDAC facilitates the exchange of ions and molecules between mitochondria and cytosol and is regulated by the interactions with other proteins and small molecules. The voltage-dependent ion channel plays a key role in regulating metabolic and energetic flux across the outer mitochondrial membrane.
-
Quinacrine是一种荧光探针，使胆碱能受体蛋白发生构象转变，低μM水平对AML细胞具有作用活性，平均IC50为2.30 μM。
More
-
JZL 184是MAGL的有效选择性抑制剂，IC50值为8nM，对FAAH的IC50值为4uM。
More
-
ESI-09是EPAC新型小分子抑制剂，能特异性阻断胞内EPAC介导的Rap1活化和Akt磷酸化，也能抑制EPAC介导的胰岛素分泌（对EPAC2和EPAC1的IC50值分别为1.4uM和3.2uM。）
More
-
Rigosertib是一种非ATP竞争性的PLK1抑制剂，IC50为9 nM，比作用于Plk2选择性高30倍，对Plk3没有抑制活性。
More
-
Pramiracetam来源于piracetam，能改善脑外伤引起的认知障碍。
More
