VDAC
VDAC (Voltage-dependent anion channels) are a class of porin ion channel located on the outer mitochondrial membrane. VDAC facilitates the exchange of ions and molecules between mitochondria and cytosol and is regulated by the interactions with other proteins and small molecules. The voltage-dependent ion channel plays a key role in regulating metabolic and energetic flux across the outer mitochondrial membrane.
-
N6022是高活性的可逆的S-亚硝基谷胱甘肽还原酶(GSNOR)抑制剂,IC50为10 nM,已进入临床开发阶段。
More
-
Carbenicillin disodium是一种半合成的青霉素抗生素,可以干扰革兰氏阴性菌细胞壁的合成,毒性低。
More
-
Taxifolin(Dihydroquercetin)是一种二氢黄酮醇(类黄酮一种),具有抗癌和抗糖尿病等多种生物学功能。
More
-
齐墩果酸(Oleanolic Acid)是一具有抗癌活性的天然化合物。
More
-
GSK461364抑制纯化的Plk1,Ki为2 nM,比作用于Plk2/3选择性高1000倍。
More