VDAC
VDAC (Voltage-dependent anion channels) are a class of porin ion channel located on the outer mitochondrial membrane. VDAC facilitates the exchange of ions and molecules between mitochondria and cytosol and is regulated by the interactions with other proteins and small molecules. The voltage-dependent ion channel plays a key role in regulating metabolic and energetic flux across the outer mitochondrial membrane.
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Allopurinol 是黄嘌呤氧化酶(XO)抑制剂,IC50为7.82±0.12 μM。
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Propylthiouraci是甲状腺过氧化物酶和5'-脱碘酶抑制剂。
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N6022是高活性的可逆的S-亚硝基谷胱甘肽还原酶(GSNOR)抑制剂,IC50为10 nM,已进入临床开发阶段。
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Carbenicillin disodium是一种半合成的青霉素抗生素,可以干扰革兰氏阴性菌细胞壁的合成,毒性低。
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Taxifolin(Dihydroquercetin)是一种二氢黄酮醇(类黄酮一种),具有抗癌和抗糖尿病等多种生物学功能。
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