VDAC
VDAC (Voltage-dependent anion channels) are a class of porin ion channel located on the outer mitochondrial membrane. VDAC facilitates the exchange of ions and molecules between mitochondria and cytosol and is regulated by the interactions with other proteins and small molecules. The voltage-dependent ion channel plays a key role in regulating metabolic and energetic flux across the outer mitochondrial membrane.
-
CID755673是细胞活性的PKD抑制剂,IC50为182 nM,与AKT,PLK1,CAK,CAMKIIα及PKC各亚型相比,可选择性抑制PKD1。
More
-
Febuxostat是选择性黄嘌呤氧化酶(XO)抑制剂,Ki为0.6 nM。
More
-
Memantine hydrochloride 是金刚胺衍生物,对NMDA受体有较弱到适中的亲和力。
More
-
Aloperine具有抗炎,抗菌,抗病毒和抗肿瘤的特性。
More
-
LY2874455能抑制FGF/FGFR介导的信号转导,有广谱抗癌活性。
More