VDAC
VDAC (Voltage-dependent anion channels) are a class of porin ion channel located on the outer mitochondrial membrane. VDAC facilitates the exchange of ions and molecules between mitochondria and cytosol and is regulated by the interactions with other proteins and small molecules. The voltage-dependent ion channel plays a key role in regulating metabolic and energetic flux across the outer mitochondrial membrane.
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Flufenamic acid是非甾体类抗炎药物, 是一种环氧合酶抑制剂,且抑制前列腺素的形成, 结合且降低前列腺素合成酶的活性, 及激活TRPC6。
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CID755673是细胞活性的PKD抑制剂,IC50为182 nM,与AKT,PLK1,CAK,CAMKIIα及PKC各亚型相比,可选择性抑制PKD1。
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Febuxostat是选择性黄嘌呤氧化酶(XO)抑制剂,Ki为0.6 nM。
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Memantine hydrochloride 是金刚胺衍生物,对NMDA受体有较弱到适中的亲和力。
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Aloperine具有抗炎,抗菌,抗病毒和抗肿瘤的特性。
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