VDAC


VDAC (Voltage-dependent anion channels) are a class of porin ion channel located on the outer mitochondrial membrane. VDAC facilitates the exchange of ions and molecules between mitochondria and cytosol and is regulated by the interactions with other proteins and small molecules. The voltage-dependent ion channel plays a key role in regulating metabolic and energetic flux across the outer mitochondrial membrane. 
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    Alfacalcidol (阿法骨化醇; 1-hydroxycholecalciferol; Alpha D3; 1.alpha.-Hydroxyvitamin D3) 是非选择性VDR活化剂。

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  • Bacitracin EY1766

    Bacitracin是由Bacillus subtilis var生物体产生的相关环状多肽组成的混合物,通过干扰细胞壁肽聚糖的合成,从而破坏革兰氏阳性和革兰氏阴性细菌。

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    BAY 57-1293作用于HSV helicase primase复合物,IC50为20 nM。

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  • 4E1RCat EY1737

    4E1RCat能抑制eIF4E与eIF4G的相互作用及eIF4E与4E-BP1的相互作用,可抑制eIF4G和eIF4E的结合,IC50为3.2 μM。

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    Epalrestat是醛糖还原酶抑制剂,可作用于糖尿病神经病变。

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