VDAC
VDAC (Voltage-dependent anion channels) are a class of porin ion channel located on the outer mitochondrial membrane. VDAC facilitates the exchange of ions and molecules between mitochondria and cytosol and is regulated by the interactions with other proteins and small molecules. The voltage-dependent ion channel plays a key role in regulating metabolic and energetic flux across the outer mitochondrial membrane.
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BAY 57-1293作用于HSV helicase primase复合物,IC50为20 nM。
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4E1RCat能抑制eIF4E与eIF4G的相互作用及eIF4E与4E-BP1的相互作用,可抑制eIF4G和eIF4E的结合,IC50为3.2 μM。
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Epalrestat是醛糖还原酶抑制剂,可作用于糖尿病神经病变。
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Ursolic acid是一天然三萜羧酸化合物,具有预防和抗癌活性。
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Deferasirox是口服铁螯合剂。
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