VDAC
VDAC (Voltage-dependent anion channels) are a class of porin ion channel located on the outer mitochondrial membrane. VDAC facilitates the exchange of ions and molecules between mitochondria and cytosol and is regulated by the interactions with other proteins and small molecules. The voltage-dependent ion channel plays a key role in regulating metabolic and energetic flux across the outer mitochondrial membrane.
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Guggulsterone can act as an antagonist ligand for farnesoid X receptor (FXR) and decrease expression of bile acid-activated genes.
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Potent inhibitor of sarco-endoplasmic reticulum Ca2+-ATPases. Causes ER stress; can be used to induce autophagy in mammalian cells.
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SF1670是一种有效的PTEN特异性抑制剂，同时对CD45具有高效抑制活性，最好的IC50数值为200 nM。
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ATN-224为铜螯合剂，抑制细胞内的SOD1活性（IC50为17.5 nM）。
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Resatorvid是TLR4信号通路抑制剂，能通过结合TLR4胞内区域抑制脂多糖诱导的炎症介质的产生。
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