VDAC


VDAC (Voltage-dependent anion channels) are a class of porin ion channel located on the outer mitochondrial membrane. VDAC facilitates the exchange of ions and molecules between mitochondria and cytosol and is regulated by the interactions with other proteins and small molecules. The voltage-dependent ion channel plays a key role in regulating metabolic and energetic flux across the outer mitochondrial membrane. 
  • SF-1670 EY2008

    SF1670是一种有效的PTEN特异性抑制剂,同时对CD45具有高效抑制活性,最好的IC50数值为200 nM。

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  • Tetrathiomolybdate EY2012

    ATN-224为铜螯合剂,抑制细胞内的SOD1活性(IC50为17.5 nM)。

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  • Resatorvid EY1900

    Resatorvid是TLR4信号通路抑制剂,能通过结合TLR4胞内区域抑制脂多糖诱导的炎症介质的产生。

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  • HOE-642 EY2000

    Cariporide (HOE-642), a potent NHE1 inhibitor, has inhibitory effects on the degranulation of human platelets, the formation of platelet-leukocyte-aggregates, and the activation of the GPIIb/IIIa receptor (PAC-1). IC50: 0.05, 3 and 1000 μM for NHE1, NHE3 and NHE2, respectively.

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  • LPS EY2001

    LPS (Lipopolysaccharide) is an endotoxin which exists as a critical glycolipid component of the outer cell wall of gram-negative bacteria. It induces apoptosis in mouse thymus and swine lymphocytes and also an activator of TLR4 and TNF receptor signaling pathways.

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