VDAC
VDAC (Voltage-dependent anion channels) are a class of porin ion channel located on the outer mitochondrial membrane. VDAC facilitates the exchange of ions and molecules between mitochondria and cytosol and is regulated by the interactions with other proteins and small molecules. The voltage-dependent ion channel plays a key role in regulating metabolic and energetic flux across the outer mitochondrial membrane.
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SR 11302 is an inhibitor of activator protein-1 (AP-1), a transcription factor that displays antitumor activity. SR 11302 does not activate transcription from the retinoic acid response element (RARE) and also does not display activity at retinoic acid receptors (EC50 > 1 μM for RARα, RARβ, and RARγ).
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SKPinc1是选择性的Skp2介导的p27降解抑制剂。
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P1 41 was a Skp2 inhibitor and was thought to prevent assembly of Skp2-Skp1 complexes.
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N6-methyldeoxyadenosine (6mA or m6A) is a DNA modification preserved in prokaryotes to eukaryotes.
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LCS 1 is an inhibitor of SOD1 (superoxide dismutase 1), an enzyme that catalyzes the conversion of superoxide ion (O2-) into H2O2 and O2 to maintain low levels of reactive oxygen species. IC50 of SOD1 = 1.07 µM。
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