VDAC
VDAC (Voltage-dependent anion channels) are a class of porin ion channel located on the outer mitochondrial membrane. VDAC facilitates the exchange of ions and molecules between mitochondria and cytosol and is regulated by the interactions with other proteins and small molecules. The voltage-dependent ion channel plays a key role in regulating metabolic and energetic flux across the outer mitochondrial membrane.
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CP-640186 hydrochloride是乙酰辅酶A羧化酶（ACCase）抑制剂，对鼠肝ACCase1和骨骼肌ACCase2的IC50s分别为53 nM和61 nM。
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AP26113是一种有效的ALK抑制剂，无细胞试验中IC50为0.62 nM，能够克服L1196M突变介导的Crizotinib耐药性。
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AZD3759是一种有效的EGFR抑制剂, 抑制EGFR TK野生型, L858R 突变型, 和 Exon 19Del 酶的IC50值分别为0.3, 0.2, 和 0.2 nM。
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ML 224 是促甲状腺激素受体TSHR反激动剂，IC50值为2.3uM。
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KDM4A/KDM4B inhibitor; inhibits histone demethylase activity on H3K9me3 and induces apoptosis in LNCaP prostate cancer cells in vitro. Also negatively regulates androgen-responsive genes.
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