VDAC
VDAC (Voltage-dependent anion channels) are a class of porin ion channel located on the outer mitochondrial membrane. VDAC facilitates the exchange of ions and molecules between mitochondria and cytosol and is regulated by the interactions with other proteins and small molecules. The voltage-dependent ion channel plays a key role in regulating metabolic and energetic flux across the outer mitochondrial membrane.
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ISO 1 is an inhibitor of MIF d-dopachrome tautomerase activity with an IC50 of about 7 uM.
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A synthetic peptide that inhibits Granzyme B.
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Peptide sequence shown to be preferred recognition motif for the serine protease granzyme B. Fluorogenic substrate.
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ILK-IN-1 is a novel ILK inhibitor with IC50 of 0.6 μM.
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CX-3543 is a fluoroquinolone derivative with antineoplastic activity. Quarfloxin disrupts the interaction between the nucleolin protein and a G-quadruplex DNA structure in the ribosomal DNA (rDNA) template, a critical interaction for rRNA biogenesis that is overexpressed in cancer cells; disruption of this G-quadruplex DNA:protein interaction in aberrant rRNA biogenesis may result in the inhibition of ribosome synthesis and tumor cell apoptosis.
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