VDAC


VDAC (Voltage-dependent anion channels) are a class of porin ion channel located on the outer mitochondrial membrane. VDAC facilitates the exchange of ions and molecules between mitochondria and cytosol and is regulated by the interactions with other proteins and small molecules. The voltage-dependent ion channel plays a key role in regulating metabolic and energetic flux across the outer mitochondrial membrane. 
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    Halofuginone is the competitively inhibitor of prolyl-tRNA synthetase with Ki of 18.3 nM.It could also down-regulate Smad3 and blocked TGF-β signaling at 10 ng/ml in mammal.

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    ISO 1 is an inhibitor of MIF d-dopachrome tautomerase activity with an IC50 of about 7 uM.

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    A synthetic peptide that inhibits Granzyme B.

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    Peptide sequence shown to be preferred recognition motif for the serine protease granzyme B. Fluorogenic substrate.

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