VDAC
VDAC (Voltage-dependent anion channels) are a class of porin ion channel located on the outer mitochondrial membrane. VDAC facilitates the exchange of ions and molecules between mitochondria and cytosol and is regulated by the interactions with other proteins and small molecules. The voltage-dependent ion channel plays a key role in regulating metabolic and energetic flux across the outer mitochondrial membrane.
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Alizarin强效抑制P450亚型CYP1A1, CYP1A2和CYP1B1,IC50分别为6.2 μM, 10.0 μM and 2.7 μM,微弱抑制CYP2A6和CYP2E1,对CYP2C19,对CYP3A4和CYP3A5没有抑制作用。
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Heparin, a highly sulfated glycosaminoglycan, is widely used as an injectable anticoagulant, and has the highest negative charge density of any known biological molecule.
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