VDAC
VDAC (Voltage-dependent anion channels) are a class of porin ion channel located on the outer mitochondrial membrane. VDAC facilitates the exchange of ions and molecules between mitochondria and cytosol and is regulated by the interactions with other proteins and small molecules. The voltage-dependent ion channel plays a key role in regulating metabolic and energetic flux across the outer mitochondrial membrane.
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Pazopanib, an orally available multi-kinase inhibitor of VEGFR, PDGFR, KIT, FGFR, as well as RAF, shows potent activity against a variety of solid tumors. Pazopanib是多重靶点抑制剂，对VEGFR1， VEGFR2，VEGFR3，PDGFR，FGFR，c-Kit 和 c-Fms的IC50分别为10 nM，30 nM，47 nM，84 nM，74 nM，140 nM和146 nM。
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Ponatinib (AP24534)是一种新型有效的作用于Abl， PDGFRα， VEGFR2， FGFR1和Src的多靶点抑制剂， IC50分别为0.37 nM， 1.1 nM， 1.5 nM， 2.2 nM和5.4 nM。
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Avitinib (AC0010) a novel mutant-selective third-generation irreversible EGFR inhibitor is currently in phase I clinical trial.
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