VDAC
VDAC (Voltage-dependent anion channels) are a class of porin ion channel located on the outer mitochondrial membrane. VDAC facilitates the exchange of ions and molecules between mitochondria and cytosol and is regulated by the interactions with other proteins and small molecules. The voltage-dependent ion channel plays a key role in regulating metabolic and energetic flux across the outer mitochondrial membrane.
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BGJ398 (NVP-BGJ398)是一种选择性的FGFR抑制剂，作用于FGFR1/2/3，IC50为0.9 nM/1.4 nM/1 nM，作用于FGFR比作用于FGFR4和VEGFR2选择性高40倍以上，对Abl， Fyn， Kit， Lck， Lyn和Yes几乎没有抑制活性。
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DMXAA (Vadimezan)是一种vascular disrupting agents (VDA)（血管阻断剂），也是一种DT-diaphorase的竞争性抑制剂，Ki为20 μM ， IC50为62.5 μM。
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SSR128129E是FGFR激酶家族变构阻断剂，能结合FGFR胞外结构域并阻断FGFR的信号转导。
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Nintedanib (BIBF 1120)是三重血管激酶抑制剂，对VEGFR1/2/3，FGFR1/2/3和PDGFRα/β的IC50分别为34 nM/13 nM/13 nM，69 nM/37 nM/108 nM和59NM。
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4μ8C是高效的选择性IRE1 Rnase抑制剂，IC50为76 nM。
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