VDAC
VDAC (Voltage-dependent anion channels) are a class of porin ion channel located on the outer mitochondrial membrane. VDAC facilitates the exchange of ions and molecules between mitochondria and cytosol and is regulated by the interactions with other proteins and small molecules. The voltage-dependent ion channel plays a key role in regulating metabolic and energetic flux across the outer mitochondrial membrane.
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Indibulin是Microtubule destabilizer。
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INDY是DYRK1A/B 抑制剂。
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INH1是Hec1 抑制剂 INH1 also causes arrest of mitosis。
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Iloprost是Prostacyclin (PGI2) 的类似物。
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PD173074是一种有效的FGFR1抑制剂,IC50约为25 nM,也能抑制VEGFR2,IC50为100-200 nM,作用于FGFR1比作用于PDGFR和c-Src选择性高1000倍左右。
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