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VDAC


VDAC (Voltage-dependent anion channels) are a class of porin ion channel located on the outer mitochondrial membrane. VDAC facilitates the exchange of ions and molecules between mitochondria and cytosol and is regulated by the interactions with other proteins and small molecules. The voltage-dependent ion channel plays a key role in regulating metabolic and energetic flux across the outer mitochondrial membrane. 

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    Rose Bengal是活性的 VGlut，VMAT 抑制剂，具有细胞膜通透性。

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    Rotenone是Rotenone inhibits complex I of the mitochondrial electron transport chain。

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  • Ro 5-3335 EI2365

    Ro 5-3335是Core binding factor的抑制剂可以削弱造血功能（hematopoiesis）。

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    Ro 61-8048是活性的 kynurenine 3-monooxygenase (KMO) 抑制剂。

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    Ro 19-4603是Benzodiazepine 反向激动剂。

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